Molecular and Proteomics Dissection of Nuclear PML Body and PRC 1 Central Spindle Organization 细胞核PMLbody动力学及PRC1中体微管构架的分子与蛋白质组学解析
These results indicate that survivin represents a link between the relocation of Aurora B kinase activity to central spindle and completion of cytokinesis. 这些结果显示,survivin把AuroraB激酶活性与中心纺锤体和胞质分裂完成联系到了一起。
Central spindle organization requires mitotic kinesins and the chromosomal passenger of Aurora B kinase complex with INCENP and survivin. 中心纺锤体的组织需要有丝分裂马达蛋白和包含AuroraB激酶,survivin,INCENP的染色体旅客蛋白复合物。
A dramatic reorganization of interpolar microtubules into a highly organized central spindle between the separating chromatids is required for the initiation and execution of cytokinesis. 在向两极分离的染色单体之间的微管很规律地重组成高度有序的中心纺锤体,这是开始和进行胞质分裂的必要条件。
Future experimentation on the spatiotemporal regulation of central spindle dynamics will elucidate the molecular orchestration between chromosome segregation and cytokinesis. 未来在中心纺锤体动力学时空调控上的研究将为我们阐明染色体分离与胞质分裂之间起着协调作用的分子机制。